World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ISOLATION, PARTIAL CHARACTERIZATION OF A FLAVANONE FROM ALBIZIA AMARA (LUGUMINACEAE) STEM BARK AND ANTIBACTERIAL ACTIVITY OF ROOT FRACTIONS

Abdel Karim M.*, Haga S., Tohami E. H. and El-Hafez M.

ABSTRACT

This study was carried out to investigate the major flavonoid of Albizia amara stem bark and to evaluate the antibacterial activity of root ethyl acetate and n-butanol fractions. The flavonoids were extracted with ethanol and the crude extract was purified by paper chromatography where a flavanone was isolated. The structure of this compound has been partially characterized by UV and 1HNMR data. In the antimicrobial assay, the ethyl acetate and n-butanol fractions from Albizia. Amara roots were assessed for antibacterial activity. These extracts showed responses against the bacterial strains: Streptococcus mutans and Lacto bacillus . Both of the ethyl acetate and the n-butanol fractions showed significant activity against Lacto bacillus within the test concentracions(100,200mg/ml). However, within the test concentrations, the ethyl acetate fraction was more effective against Streptococcus mutans than the n-butanol fraction.

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