World Journal of
Pharmaceutical and Life Sciences

ANTIBIOTIC DRUG QUALITY EVALUATION: DETERMINATION OF CEFADROXIL USED IN TREATMENT IN THE CASE OF RESISTANCE AT TASIKMALAYA CITY HEALTH CENTER, INDONESIA

Danni Ramdhani*, Wiwiek Indriyati and Muhammad Aiman

ABSTRACT

Objective: Cefadroxil is one of the choices of antibiotics used in the management of Acute Respiratory Infection (ARIs) disease treatment. The good quality of antibiotics greatly determines the effectiveness and success in therapy. The level of an antibiotic is one of the quality parameters that must meet the requirements stated in the United State Pharmacopeia (USP). Methods: The cefadroxil antibiotic used in the treatment of ARIs was obtained from the health center of the City of Tasikmalaya. The determination of cefadroxil was carried out using HPLC instruments, using validation parameters linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ). Results: The test results showed that the levels of levofloxacin antibiotics that are used to meet the requirements that exist in the United State Pharmacopeia grading 107.58 %, and the validation parameters that meet the requirements, correlation coefficient of 0.9999, recovery percent of 99.67 %, precision 0.06 %, LOD 0.5013 ?g/mL and LOQ 1.519 ?g/mL. Conclusions: The test results showed that the levels of cefadroxil antibiotics that are used to meet the requirements that exist in the United State Pharmacopeia (USP).

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